Hongji Yan, postdoctoral researcher in the group is the lead author of “Immune‐Informed Mucin Hydrogels Evade Fibrotic Foreign Body Response In Vivo.” Advanced Functional Materials 14 (September): 1902581. along with several other authors including

  • Cédric Seignez and Mia Phillipson, from Uppsala university that contributed with in vivo work.
  • Morgan Hjorth, Matthew Blakeley from our group that helped with RT-PCR and imaging
  • Benjamin Winkeljann and Oliver Lieleg from TU Munich that helped with rheology.

A beautiful collaboration that lead to what we believe is an important landmark paper, establishing mucin-based materials as bioactive and immune-modulating. The manuscript describes how mucin-materials impact the recruitment and activity of immune cells when implanted in mice. It also show that the mucin-materials avoid the fibrous encapsulation that implants typically undergo when left from more than 2 weeks in a host.

This work is important for at least two reasons.

  1. We hope this work will inspire many others to consider mucins and mucin-like molecules as a building blocks to construct the next generations of bioactive, bio-informed materials that provide both the physical and the biological features needed for advanced functionalities.
  2. The evasion of fibrosis of mucin-hydrogel is an interesting feature that can be directly used to improve the outcome of long-term medical implants. This includes electrodes, sensors, and encapsulated cells.

Further work is now being done to test the functionalities of other materials derived from mucins and test whether mucins gels can sustain the survival of cells in the gel for extended periods of time.

The paper is accessible from the publisher’s website, and a pre-print version on BioRxiv.

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December 1st, 2016

2nd workshop on protein materials – March 9-10, 2017

The 2nd Workshop on Protein Materials will be organised March 9-10, 2017 at KTH (Stockholm, Sweden)

October 31st, 2016

Opportunities with the KTH – CSC Programme

CSC-KTH programme offers scholarship opportunities for Chinese students and postdocs.

September 22nd, 2016

New PhD position – Here’s what you should know

We are recruiting a PhD student. So what is expected and what can you expect?

September 14th, 2016

Grant proposal – Methylcellulose as next generation microbial culture substrate

I am publishing a grant application submitted to the Swedish Research Council FORMAS in 2016.

August 10th, 2016

A call for better mucins

We need to push for better quality commercial mucins to advance the many scientific fields relying on mucins molecules.

July 24th, 2016

Join us at the ESOF 2016, the EuroScience Open Forum!

The EuroScience Open Forum is one of the most important general science conference of the world.

April 6th, 2016

We will be at the World Biomaterials Congress in Montreal – May 2016

Come meet us at the world’s largest biomaterials conference!

March 17th, 2016

Mucus, it’s snot what you think (video)!

The Materials Research Society Foundation generously funded us to create this fun video on the usefulness of mucus! We based […]

February 15th, 2016

Citizen Science to the rescue!

The concept of Citizen Science has attracted a lot of attention over the past few years. But most of us scientists […]

January 24th, 2016

Exploring the surface with OpenQCM

The surface properties of a material are especially important in the case of implantable biomaterials, since it is the surface of the […]