Update: this made the news on the KTH website (Swedish version)!

We are happy to announce a new publication in the ACS Biomacromolecules journal (doi: 10.1021/acs.biomac.7b01670, openly accessible through our publication list). The paper describes the reinforcement of the mucus barrier with short chitosan molecules. This work is a continuation of the mucus engineering work started late 2011 that led to a first publication in 2015 on the modification of mucin molecules to restore mucosal hydration and lubrication. In this new work, the goal was to find a way to modulate another important function of the mucus gel: its ability to act as a barrier against deleterious molecules and pathogens. The work is the result of a collaboration between our group at KTH (Stockholm, Sweden) and researchers at the Claude-Bernard University (Lyon, France) and Uppsala University (Uppsala, Sweden).


Reinforcing the barrier properties of mucus with chitosans.

This new publication describes the possibility of using chitosans to reinforce the barrier properties of mucus. Chitosans are natural molecules that are extracted from the shell of shrimps or the tissues of mushrooms. We show that if made small enough, chitosan molecules are able to diffuse into the mucus and strongly bind to the fibers that make up mucus.

The chitosan molecules then form bridges between the fibers, closing the pore of the mucus, and making it harder for molecules to penetrate. Chitosans are already widely used in the food and medical industries and are generally recognized as safe. We also saw no negative significant effect of the chitosans on the viability of epithelial cells cultured in vitro.

Modification of mucus by such a topical treatment could become a new way to address the breakdown of the mucus barrier in diseases such as inflammatory bowel disease or gastric ulcers. Of course, many challenges remain before this technology is ready to be translated clinically, including testing the approach on more complex mucus materials and tackling the challenge of delivery.


Following up with applications.

Our lab now continues to explore the potential of mucosal topical treatments to tune the properties of mucus. Chitosans are particularly interesting to use in that regard. For instance, Dr. Ulrike Schimpft has started to test the use of chitosans to prevent sperm cells from penetrating human cervical mucus. The project aim is to create the basis for a new generation of non-hormonal contraceptives for women in partnership with the Circle Biomedical company. More information regarding these exciting advances will come soon!

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February 11th, 2020

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December 27th, 2019

New article on chitosan biocompatibility

October 3rd, 2019

Congratulation to Hongji for his latest paper on in vivo immune modulation of mucin hydrogels

May 27th, 2019

Congratulations to Georgia Petrou for graduating!

May 25th, 2019

Welcome to our new lab members

February 27th, 2019

New video of our work

January 7th, 2019

Looking for a postdoc in slime?

January 2nd, 2019

Protein Materials Conference 7-8th March 2019

December 13th, 2018

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New publication: Reversible Condensation of Mucins into Nanoparticles