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Congratulations to Georgia Petrou, who is leading author on our latest publication in Biomacromolecules. Genetically engineered mucoadhesive spider silk by Georgia Petrou, Ronnie Jansson, Mark Högqvist, Johan Erlandsson, Lars Wågberg, My Hedhammar, and Thomas Crouzier. The article is accessible via the publisher’s website (paywall) and on our website (green open access).

The work was initiated in 2017 by Mark Högqvist, a master student in the Master Biotechnology program at KTH in very close collaboration with the group of My Hedhammar (and in particular Ronnie Jansson). My and her group has developed an impressive platform technology that allows virtually any bio-functionalities to be included in silk materials by using recombinantly-produced engineered silk proteins.

The challenge in this work was to create a material that could combine the advantages of spider silk, which is strong, biocompatible, biodegradable, nontoxic and lightweight and be mucoadhesive. Such a mucoadhesive material could be used to develop mucosal wound dressings, and noninvasive transmucosal drug delivery systems.

We investigated two variants of the partial spider silk protein. A first variant functionalized with six positively charged charged lysines to bind to the negatively charged mucins electrostatically. And a second variant, containing the human Galectin-3 Carbohydrate Recognition Domain which specifically binds the glycans that are present in mucins. We showed that the coatings, the meshes, and the foams produced from these silk variants can bind strongly to mucins and could thus be used as a useful building block of functional mucoadhesive materials.

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  Posts

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November 19th, 2018

New publication: Reversible Condensation of Mucins into Nanoparticles

October 15th, 2018

Welcome to Gilai and Laise

July 30th, 2018

New review published: Mucins as multifunctional building blocks of biomaterials

July 9th, 2018

New publication: Muco-silk, an mucoadhesive engineered silk

June 26th, 2018

Thank you to the master and bachelor students of Spring 2018!!

March 7th, 2018

New mucus engineering publication from the group.

January 26th, 2018

Welcome to three new students!

August 21st, 2017

iGEM Stockholm 2017 engineering mucus – Update with gold!

August 18th, 2017

Welcome to Ulrike Schimpf and Cristina Chircov!

July 13th, 2017

Mucin-inspired lubrication on hydrophobic surfaces