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logotype_enA new project funded by the Swedish research council FORMAS will start in the group in 2016. We will be hard at work setting up mucin purification protocols in the lab and start working on mucin-based biomaterials. Here is a quick summary of the approved, which was funded 1 million swedish krona per years (~108 keuros), for 3 years.

Extraction, characterization, and use of mucin biopolymers for biomedical applications.

For thousands of years, and still today, humans have exploited natural materials for their benefit. For instance, wood-extracted cellulose fibers are used to make paper and animal-extracted hyaluronic acid is used in cosmetic anti wrinkle creams. In this proposal we will develop the use of mucins, i.e. a molecules extracted from mucus, for biomedical applications. Mucins are the main components of mucus, the gel that covers the wet epithelium of all mammals. Commonly secreted by animal tissues, they can be extracted from abundant sources such as pig stomachs and bovine submaxillary glands.

The study and technological use of mucins are hampered by the poor control over the quality of the mucins available. In this proposal, we first aim to develop a quality-control benchmark by measuring a series of physical and biochemical properties. Using this benchmark, we will then identify new processes to efficiently extract biomedical-grade mucin glycoproteins from animal tissues. Then, we will use high quality mucins to investigate their potential as a new building block for a new generation of medical devices. In particular, we will test the ability of pig gastric mucins to be assembled into hydrogels for the delivery of the epidermal growth factor (EGF). EGF is naturally found in the context of mucins, and could thus benefit from its association in an implantable material. Such material could serve as wound dressing to treat severe wounds.

 

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  Posts

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October 15th, 2018

Welcome to Gilai and Laise

July 30th, 2018

New review published: Mucins as multifunctional building blocks of biomaterials

July 9th, 2018

New publication: Muco-silk, an mucoadhesive engineered silk

June 26th, 2018

Thank you to the master and bachelor students of Spring 2018!!

March 7th, 2018

New mucus engineering publication from the group.

January 26th, 2018

Welcome to three new students!

August 21st, 2017

iGEM Stockholm 2017 engineering mucus – Update with gold!

August 18th, 2017

Welcome to Ulrike Schimpf and Cristina Chircov!

July 13th, 2017

Mucin-inspired lubrication on hydrophobic surfaces

March 27th, 2017

Get funded in Sweden. A guide for starting researchers.